Research Progress--Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

11

2015-06

Researchers at Institut Pasteur of Shanghai identify a key molecular pathway for the inactivation of Treg cells after sensing inflammation

Activity of the forkhead family transcription factor FOXP3 determines the immune function of FOXP3+Regulatory T cells (Tregs). Upon infection or other inflammatory conditions, FOXP3+Tregs may suppress effector immune cell responses leading to the failure of clearing infection or autoimmunity. FOX...Activity of the forkhead family transcription factor FOXP3 determines the immune function of FOXP3+Regulatory T cells (Tregs). Upon infection or other inflammatory conditions, FOXP3+Tregs may suppress effector immune cell responses leading to the failure of clearing infection or autoimmunity. FOX...

20

2015-05

Researchers at Institut Pasteur of Shanghai discoveranew mechanism for restricting Hepatitis C Virusinfection by host innate immunity

Hepatitis C virus (HCV) is an important human pathogen that causes chronic liver diseases including hepatitis, liver cirrhosis and hepatocellular carcinoma. The tremendous progress has been achieved in the therapeutics of HCV thanks to the development of direct antiviral agents, but the worldwide...Hepatitis C virus (HCV) is an important human pathogen that causes chronic liver diseases including hepatitis, liver cirrhosis and hepatocellular carcinoma. The tremendous progress has been achieved in the therapeutics of HCV thanks to the development of direct antiviral agents, but the worldwide...

20

2015-05

SHP-2 regulates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses

Fungal infections are regarded as a serious health threat worldwide because they cause severe mucosal and systemic candidiasis in elderly people and patients with AIDS, organ transplantation or immunodeficiency. C-type lectin receptors (CLRs) dectin-1, dectin-2/3 and Mincle play a pivotal role in...Fungal infections are regarded as a serious health threat worldwide because they cause severe mucosal and systemic candidiasis in elderly people and patients with AIDS, organ transplantation or immunodeficiency. C-type lectin receptors (CLRs) dectin-1, dectin-2/3 and Mincle play a pivotal role in...

20

2015-05

SHP-2 regulates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses

Fungal infections are regarded as a serious health threat worldwide because they cause severe mucosal and systemic candidiasis in elderly people and patients with AIDS, organ transplantation or immunodeficiency. C-type lectin receptors (CLRs) dectin-1, dectin-2/3 and Mincle play a pivotal role in...Fungal infections are regarded as a serious health threat worldwide because they cause severe mucosal and systemic candidiasis in elderly people and patients with AIDS, organ transplantation or immunodeficiency. C-type lectin receptors (CLRs) dectin-1, dectin-2/3 and Mincle play a pivotal role in...