Research Progress--Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

24

2019-07

Institut Pasteur identifies metabolic ALARMIN factors mediating local-systemic innate immune communication

Across metazoans, scaling the level of the tissue damage or pathogen invasion by the local immunity is a pivotal sensing and alarming step for the fine-tuned systemic immunity. Thus, interorgan communication is critical to help maintain the homeostasis of the local-systemic immunological crosstal...

06

2019-06

China approves norovirus vaccine for clinical trial

Chinese authorities have greenlit a clinical trial for the world's first tetravalent vaccine against norovirus, the most common cause of viral gastroenteritis.
　　The vaccine received the clinical research permit from the National Medical Products Administration on May 30, its developer, the Ins...

12

2019-02

Discovery of molecular mechanism of DNA helicase PfRecQ1 regulating the mutually exclusive expression of virulence genes in Plasmodium falciparum

The research work, entitled "DNA helicase RecQ1 regulates mutually exclusive expression of virulence genes in Plasmodium falciparum via heterochromatin alteration" has been published online in the Journal of "Proceedings of the National Academy of Sciences of the United States" on February 6, 201...

26

2018-12

Institut Pasteur of Shanghai develops an epigenetic editing system by CRISPR/dCas9 in Plasmodium falciparum

The research work, entitled "Epigenetic editing by CRISPR/dCas9 in Plasmodium falciparum" has been published online in the Journal of "Proceedings of the National Academy of Sciences of the United States" on December 24, 2018.
　　Malaria, AIDS and tuberculosis are listed as the world's three maj...