Research Progress--Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

13

2012-01

A Human Antibody Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses

Int/csr/disease/avian_influenza/).Current vaccines against H5N1 virus provide immunity to viral isolates similar to vaccine strains. High affinity neutralizing antibodies against conserved epitopes could provide immunity to diverse influenza strains and protection against future pandemic viruses....On January 11, 2012, Journal of Virology published online a research article entitled “A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses” by Paul Zhou’s laboratory at the Institut Pasteur of Shanghai, Chinese...

13

2012-01

A Novel Approach to produce Human Monoclonal Antibody

Thus developing reliable culture conditions for the large scale human monoclonal antibody production are practically important. Since it was introduced in late 1990s Wave bioreactor has been used for protein production by mammalian and insect cells. These results strongly support for using Wave b...On December 25, 2011, Molecular Biotechnology published online a research article entitled “High Yield of Human Monoclonal Antibody Produced by Stably Transfected Drosophila Schneider 2 Cells in Perfusion Culture Using Wave Bioreactor” by Paul Zhou’s laboratory at the Institut Pasteur of shang...

08

2011-12

Penicillium marneffei-stimulated dendritic cellsenhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells

Penicillium marneffei (P. marneffei) is considered an indicator pathogen of AIDS, and the endemicity and clinical features of P. marneffei have been described. While, how the co-infection of P. marneffei exacerbate deterioration of the immune response remains poorly understood.
　　Professor WANG...

06

2011-12

New mechanism of cross-species adaptation for avian influenza virus

Prof. SUN Bing with his team at Shanghai Institute of Pasteur, CAS, found that PB1 of avian influenza A virus contributes to higher polymerase activity than PB1 from human influenza A virus, and 473V and 598P are responsible for this role. This founding indicates a new mechanism for adaptation of...