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Virus assembly and host dependency (Gang Long)

Date:12-02-2017   |   【Print】 【close

The establishment of the cell culture model for HCV infection facilitates molecular virology research on HCV characteristics and its interaction with host cells. HCV utilizes multiple receptor molecules to gain functional entry. HCV infection induces membrane rearrangement for efficient genome replication. And with help of host lipoprotein production machinery, HCV assembles as lipo-viral particles. Major interest of our research team is, based on recent progresses, to study the mechanism underlying interactions between HCV and host apolipoproteins. We hope more precise knowledge on this aspect would pave the way to the development of novel strategy to control HCV infection.