virus-associated lymphomagenesis (Xiaozhen Liang)
The B-cell lymphomas develop more frequently in older adults and immunocompromised individuals, such as those with AIDS, bone marrow or organ transplantation patients. Malignant B-cell lymphomas have been the second most frequent malignancy in HIV-infected population, even overtaken other cancers as the most frequent AIDS-associated diseases in some HIV cohorts. The B-cell lymphomas, especially in the populations with impaired immune control and chronic inflammation caused by HIV infections or immunosuppressive drug administration, are tightly associated with opportunistic human gammaherpesvirus infection, Kaposi’s sarcoma herpesvirus (KSHV) and/or Epstein-Barr virus (EBV) infection. However, how gammaherpesvirus infection regulates B-cell lymphomagenesis, especially under immunocompromised setting, remains largely unknown.
The main focus in my lab is to study viral pathogenesis in B-cell lymphoma development by utilizing a novel viral transformation system of fetal liver-derived B-cells (FLC) with murine gammaherpesvirus 68 (MHV68) infection, and a novel mouse model developed recently (Fig. 1), aiming to understand the molecular mechanisms of virus-associated B-cell lymphomagenesis in vitro and in vivo and explore the new therapeutic strategies.