Pathogen-host interaction and Epigenetics(Lubin Jiang)
Both eukaryotic and prokaryotic pathogens infect host stably via an immune evasion mechanism termed mutually exclusive expression. Nowadays, little is known about this epigenetic mechanism, largely limiting understanding of pathogenesis of many bacterial, fungal and protozoan pathogens and development of novel drugs and vaccines. Our lab aims to elucidate the molecular mechanisms and biological consequences of epigenetic and genetic factors (histone modifications, lncRNA, transcription factors, etc.) of pathogen and host interaction in major infectious diseases caused by such as HIV, TB, and Plasmodium falciparum, with the long-term view toward the design of novel drugs, vaccines and diagnosis.