Our research interests focus on the interactions of HIV-1-host cells and viral pathogenesis, and three aims are included:
Aim1#: HIV-1 mucosal infections and host cell-mediated viral dissemination;
Aim2#: The contribution of dendritic cells immunal activation to viral pathogenesis during co-infections of HIV-1 with other pathogens;
Aim3#: To explore the host factors that could restrict HIV-1 replication in monocytic cells.
Dendritic cells interact with HIV-1 (green, Vpr-GFP)
and transmit HIV to human CD4+ T cells.