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  Arbovirus Interspecies Transmission and Therapeutics Research Unit(Dimitri LAVILLETTE)

_ Guillemette Maurin, Boris Halgand, Patrice Bruscella, Judith Fresquet, Jean-Charles Duclos-Vallée, Anne-Marie Roque-Afonso, François-Loïc Cosset, Didier Samuel, Dimitri Lavillette*, Cyrille Féray*. Low cross neutralization of Hepatitis C virus correlates with liver disease in immunocompromized patients. Accepted in AIDS. 2015.

_ Douam F, Dao Thi VL, Maurin G., Fresquet J., Mompelat D., Cosset FL and Lavillette D. A critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry. Hepatology. 2014 Mar;59(3):776-88.

_ Murphy L, Varela M, Desloire S, Ftaich N, Murgia C, Golder M, Neil S, Spencer TE, Wootton SK, Lavillette D, Terzian C, Palmarini M, Arnaud F. The sheep tetherinparalog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions. J Virol. 2015 Jan;89(1):535-44. doi: 10.1128/JVI.02751-14. Epub 2014 Oct 22.

_ Girard-Gagnepain A, Amirache F, Costa C, Lévy C, Frecha C, Fusil F, Nègre D, Lavillette D, Cosset FL, Verhoeyen E. Baboon envelope pseudotypedlentiviral vectors outperform VSV-G pseudotypedlentiviral vectors for gene transfer into cytokine-stimulated and resting hematopoietic stem cells. Blood.2014 Jun 20.

_ Lévy C, Aerts L, Hamelin MÈ, Granier C, Szécsi J, Lavillette D, Boivin G, Cosset FL. Virus-like particle vaccine induces cross-protection against human metapneumovirus infections in mice. Vaccine. 2013 Jun 7;31(25):2778-85

_ Garrone P, Fluckiger AC, Mangeot PE, Gauthier E, Dupeyrot-Lacas P, Mancip J, Cangialosi A, Du Chéné I, Legrand R, Mangeot I, Lavillette D, Bellier B, Cosset FL, Tangy F, Klatzmann D, Dalba C. A prime-boost strategy using virus-like particles pseudotyped for HCV proteins triggers broadly neutralizing antibodies in macaques. SciTransl Med. 2011 Aug 3;3(94):94

_ Maurin G, Fresquet J, Granio O, Wychowski C, Cosset FL and Lavillette D. Identification of interactions in the E1E2 heterodimer of Hepatitis C virus important for cell entry. J Biol Chem. 2011 Jul 8;286(27):23865-76

_ Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D,Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoël M, Raffelsberger W, Poch O, McKeating JA, Brino L, Baumert TF. EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med. 2011 May;17(5):589-95.

_ Lin EH, Salon C, Brambilla E, Lavillette D, Szecsi J, Cosset FL, Coll JL. Fusogenic membrane glycoproteins induce syncytia formation and death in vitro and in vivo: a potential therapy agent for lung cancer. Cancer Gene Ther. 2010 Apr;17(4):256-65. 2009 Nov 6.

_ Trotard M, Lepère-Douard C, Régeard M, Piquet-Pellorce C, Lavillette D, Cosset FL, Gripon P, Le Seyec J. Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening. FASEB J. 2009 Nov;23(11):3780-9.

_ Dreux M, Dao Thi VL, Fresquet J, Guérin M, Julia Z, Verney G, Durantel D, Zoulim F, Lavillette D, Cosset FL, Bartosch B. Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains. PLoSPathog. 2009 Feb;5(2):e1000310. Epub 2009 Feb 20.

_ Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T. The tight junction proteins claudin-1, -6 and -9 are entry cofactors for the Hepatitis C virus. J Virol.2008; 82:3555-3560.

_ Lavillette D, Pecheur EI, Donot P, Fresquet J, Molle J, Corbau R, Dreux M, Penin F, Cosset FL. Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus. J Virol. 2007 Aug;81(16):8752-65.

_ Lavillette D, Barbouche R, Yao Y, Boson B, Cosset FL, Jones IM, Fenouillet E. Significant redox insensitivity of the functions of the SARS-CoV Spike glycoprotein; comparison to HIV envelope. J Biol Chem. 2006 Apr 7;281(14):9200-4.2006.

_ Lavillette D., Y. Morice, G. Germanidis, P. Donot, A. Soulier, E. Pagkalos, G. Sakellariou, L. Intrator, B. Bartosch, J.-M. Pawlotsky, and F.-L. Cosset. 2004. Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection. J Virol. 2005 May;79(10):6023-34.

_Lavillette D, Tarr AW, Voisset C, Donot P, Bartosch B, Bain C, Patel AH, Dubuisson J, Ball JK, Cosset FL. Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus. Hepatology. 2005 Feb;41(2):265-74.

_ Lavillette D and Kabat D. Porcine endogenous retroviruses infect cells lacking cognate receptors by an alternative pathway: implications for retrovirus evolution and xenotransplantation. J Virol. 2004 Aug;78(16):8868-77


Reviews, Book chapter:

Douam F, Lavillette D, Cosset FL. The mechanism of HCV entry into host cells.ProgMolBiolTransl Sci. 2015;129:63-107. doi: 10.1016/bs.pmbts.2014.10.003. Epub 2014 Dec 12.

FL Cosset and D Lavillette. Cell entry of enveloped viruses.Advances in Genetics. 2011;73:121-83.

Pérot P*, Montgiraud C*, Lavillette D* and Mallet F.A comparative portrait of retroviral fusogens and syncytins.Cell Fusions book. 2011. pp 63-115, Springer


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