Under the guidance of Principal Investigator Li Bin and Chief Physician Lv Lin, PhD Yang Jing from immune molecule group of Institut Pasteur of Shanghai, master studentWang Xiuwen from rheumatism department of Fudan university Huashan hospital and theircolleagues showed that tumor necrosis factor receptor associated factor 5 (TRAF5), known as an E3 ubiquitin-protein ligase and signal transducer, interacts with and ubiquitinatesRORγt via K63-linked polyubiquitination. And depletion of TRAF5 in Th17 cells destabilizes RORγt protein and down-regulates Th17-related genes. Moreover, up-regulation of TRAF5 mRNA level was found in SLE patient CD4+ T cells. The study not only shed lights on the regulation of Th17 lineage by ubiquitination but also provided new explanation on the role of Th17 cells and potential therapeutic targets towards autoimmune diseases.
The research is supported by Chinese National Program on Key Basic Reasearch Project, Natural Science Foundation of China, Shanghai Key grant and Shanghai Three-year Plan on Promoting TCM Development.