Home | Contact | Sitemap | 中文 | CAS  
 
  Home > PUBLIC HEALTH EDUCATION > lecture
Norovirus

The following questions were raised by “Xinmin Weekly”, answered by Prof. Tetsuya Toyoda, Principal Investigator, Unit of Viral Genome Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences.
January 17, 2007

Xinmin Weekly question (hereafter refer to Q): Norovirus is not a new virus,Why there is a severe Norovirus epidemic in the world recently Norovirus

Tetsuya Toyoda (hereafter refer to A): Norovirus is a newly classified virus as a member of the family Caliciviridae at the 8h International Committee on Taxonomy of Viruses in 2002 though it was discovered in 1968 when the virus was termed as Norwalk virus. Human is the only host of Norovirus and we do not have any cell culture system of Norovirus. We have not been able to diagnose Norovirus infection until recently when we developed antibodies and virus like particles of Norovirus and developed RT-PCR or real time RT-PCR system from the sequence data of Norovirus conserved regions. I would like to comment that the development of its diagnosis method revealed its infection, resulting in an apparent increase of Norovirus infection in these years in Japan.

Q: In Japan, what’s the difference between the Norovirus epidemic in 2006 and before Is it related between taking raw seafood and Norovirus infection
A: In Japan, there were always Norovirus epidemic in the winter season since 2002. Some of them were related with oyster and raw sea foods. In 2006 Japanese journalism focused on the Norovirus epidemic and victims’ death in nursing homes. In 2006-2007, the case number of Norovirus infection was almost tripled of that before (https://hasseidoko.mhlw.go.jp/Byogentai/Pdf/data9e.pdf).
Japan studied its epidemiology as SRSV (small round shaped-like virus) which included Norovirus since 1997 before Norovirus was classified, and has studied it as Norovirus infection since 2003. There was no death from Norovirus infection in Japan before 2005. In 2006, Japanese epidemic of Norovirus infection were reported from nursing homes, nursery and elementary schools. This epidemic was not related with raw seafoods.


year

2000

2001

2002

2003

2004

2005

case

245

269

268

278

277

274

patient

8,080

7,358

7,961

10,603

12,537

8,727

death

0

0

0

0

0

0

From http://www.mhlw.go.jp/topics/syokuchu/kanren/yobou/040204-1.html#04

Q: It is said there are 12 Japanese died of Norovirus. What’s the death cause of Norovirus infected people What’s the death rate of Norovirus
A: The victims were aged person in nursing homes and died from pneumonia or choking by aspiration of vomit. The qualification of the victims are not released but I should point out that the many aged people in Japanese nursing homes are disabled both in physically and mentally because of brain stroke or dementia. I do not want to include these victims in the death of Norovirus infection. I am not sure about the death number of Norovirus infection in Japan. I am not sure if the death number reported in Japanese paper is included in the official statistics.

Download
  Go to lecture     TOP
 
HOME|PRESS|CAREER|PUBLIC HEALTH EDUCATION | CONTACT US|LINKS
沪ICP备10017196号  2010 Copyright by Institut Pasteur of Shanghai, Chinese Academy of Sciences

Address: Life Science Research Building 320 Yueyang Road, Xuhui District, 200031, Email: ips@sibs.ac.cn