Latest News--Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

13

2012-01

A Novel Approach to produce Human Monoclonal Antibody

Thus developing reliable culture conditions for the large scale human monoclonal antibody production are practically important. Since it was introduced in late 1990s Wave bioreactor has been used for protein production by mammalian and insect cells. These results strongly support for using Wave b...On December 25, 2011, Molecular Biotechnology published online a research article entitled “High Yield of Human Monoclonal Antibody Produced by Stably Transfected Drosophila Schneider 2 Cells in Perfusion Culture Using Wave Bioreactor” by Paul Zhou’s laboratory at the Institut Pasteur of shang...

08

2011-12

Penicillium marneffei-stimulated dendritic cellsenhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells

Penicillium marneffei (P. marneffei) is considered an indicator pathogen of AIDS, and the endemicity and clinical features of P. marneffei have been described. While, how the co-infection of P. marneffei exacerbate deterioration of the immune response remains poorly understood.
　　Professor WANG...

06

2011-12

New mechanism of cross-species adaptation for avian influenza virus

Prof. SUN Bing with his team at Shanghai Institute of Pasteur, CAS, found that PB1 of avian influenza A virus contributes to higher polymerase activity than PB1 from human influenza A virus, and 473V and 598P are responsible for this role. This founding indicates a new mechanism for adaptation of...

11

2011-11

The researchers at Institut Pasteur of Shanghai discover different susceptibilities to Japanese encephalitis virus neuroinvasion in mice

Only a limited number of JEV-infected individuals show symptoms and induce severe encephalitis,that indicating host-dependent susceptibilities. The reason that people have different susceptibilities to JEV remains unclear. Clinical manifestations of JEV infections in laboratory mice closely resem...Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus. The infectious disease it causes is encephalitis. China is one of the countries with high incidence of encephalitis. Only a limited number of JEV-infected individuals show symptoms and induce severe encephalitis, that indicating h...