Researchers at Institut Pasteur of Shanghai identify a key molecular pathway for the inactivation of Treg cells after sensing inflammation
Fig. A. FOXP3 complex were purified by tandem affinity purification in T cells.
Fig. B. DBC1 knockdown or Casapase 8 knockdown human Treg cells maintain more FOXP3 proteins.
Fig.C.Dbc1-/- mice develop less severe autoimmune disease symptoms during EAE induction.
Fig.D.Dbc1-/-Treg cells function profoundly in preventing colitis.